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Researchers at Guangxi University (GXU) have recently reported new progress in the development of molecular probes for detecting lung aging, offering a potential new tool for early assessment of smoking-related lung damage. The findings, published online in the international journal Science China Chemistry under the title “A Photoacoustic Probe for In Vivo Detection of Lung Aging: Toward a Strategy for the Prevention of Smoking-Induced Lung Lesions,” present a novel approach for monitoring lung aging processes directly in living organisms.

The study was conducted by the Probe and Chemical Biology research team from the School of Chemistry and Chemical Engineering at GXU. Doctoral student Li Zihong is the first author of the paper, with Professor Lin Weiying serving as the corresponding author. GXU is the sole corresponding institution.

Aging is a highly individualized biological process shaped by a complex interplay of genetic factors, environmental influences, lifestyle choices, and overall health conditions. Among the many indicators of physiological aging, the condition of the lungs is regarded as a key marker of long-term health. However, despite its importance, reliable technologies capable of assessing lung aging directly in living organisms remain limited.

To address this challenge, the GXU research team designed and synthesized a new photoacoustic probe known as SHLGAL, enabling the detection of lung aging at the in vivo level for the first time. Experimental results demonstrate that the probe can selectively respond to the aging-associated biomarker β-galactosidase, showing strong detection performance both in laboratory experiments and in living systems.

Building on this probe, the researchers further integrated SHLGAL with photoacoustic imaging technology to develop a convenient and noninvasive detection strategy called the ChemBio Imaging Approach (CBIA). Using this method, the team was able to monitor the progression of smoking-induced lung aging in experimental models. The study also revealed, for the first time, that the compounds dasatinib and quercetin may have a potential preventive effect against lung damage caused by smoking, pointing to new possibilities for early intervention to lung diseases.

By providing a practical strategy for detecting lung aging in living organisms, this research establishes a new technological pathway for studying age-related lung changes. At the same time, it offers valuable insights for the design and application of next-generation functional probes, highlighting the broad potential of interdisciplinary research at the intersection of chemistry, biology, and biomedical science.